PNPLA3 gene predicts clinical recovery after sustained virological response in decompensated hepatitis C cirrhosis.
Identifieur interne : 000587 ( Main/Exploration ); précédent : 000586; suivant : 000588PNPLA3 gene predicts clinical recovery after sustained virological response in decompensated hepatitis C cirrhosis.
Auteurs : Winston Dunn [États-Unis] ; Anusha Vittal [États-Unis] ; Jie Zhao [États-Unis] ; Jianghua He [États-Unis] ; Shweta Chakraborty [États-Unis] ; Melissa Whitener [États-Unis] ; Sara Fohn [États-Unis] ; Ryan Ash [États-Unis] ; Ryan M. Taylor [États-Unis] ; Mojtaba Olyaee [États-Unis] ; Jody C. Olson [États-Unis] ; Nancy Todd [États-Unis] ; Beth N. Floyd [États-Unis] ; Prashant Pandya [États-Unis] ; Melissa Laycock [États-Unis] ; Timothy Schmitt [États-Unis] ; Steven A. Weinman [États-Unis]Source :
- BMJ open gastroenterology [ 2054-4774 ] ; 2019.
Abstract
Background
Patients with decompensated hepatitis C virus (HCV) cirrhosis experience various outcomes after sustained virological response (SVR), ranging from clinical recovery to further deterioration. We hypothesised that the genetic risk for steatosis, namely the polymorphisms rs738409 of Patatin-like Phospholipase Domain-Containing 3 (
Methods
We prospectively enrolled 56 patients with Child-Pugh (CPT) B/C cirrhosis who underwent antiviral therapy. The primary outcome was change in CPT score at 12, 24, and 48 weeks after SVR. We used a linear mixed-effects model for analysis.
Results
Forty-five patients (
Conclusion
The
DOI: 10.1136/bmjgast-2018-000241
PubMed: 30997139
PubMed Central: PMC6441264
Affiliations:
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Taylor</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Olyaee, Mojtaba" sort="Olyaee, Mojtaba" uniqKey="Olyaee M" first="Mojtaba" last="Olyaee">Mojtaba Olyaee</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Olson, Jody C" sort="Olson, Jody C" uniqKey="Olson J" first="Jody C" last="Olson">Jody C. Olson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Todd, Nancy" sort="Todd, Nancy" uniqKey="Todd N" first="Nancy" last="Todd">Nancy Todd</name><affiliation wicri:level="2"><nlm:affiliation>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Floyd, Beth N" sort="Floyd, Beth N" uniqKey="Floyd B" first="Beth N" last="Floyd">Beth N. Floyd</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Pandya, Prashant" sort="Pandya, Prashant" uniqKey="Pandya P" first="Prashant" last="Pandya">Prashant Pandya</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Kansas City VA Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Kansas City VA Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Laycock, Melissa" sort="Laycock, Melissa" uniqKey="Laycock M" first="Melissa" last="Laycock">Melissa Laycock</name><affiliation wicri:level="2"><nlm:affiliation>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Schmitt, Timothy" sort="Schmitt, Timothy" uniqKey="Schmitt T" first="Timothy" last="Schmitt">Timothy Schmitt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Weinman, Steven A" sort="Weinman, Steven A" uniqKey="Weinman S" first="Steven A" last="Weinman">Steven A. Weinman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30997139</idno><idno type="pmid">30997139</idno><idno type="doi">10.1136/bmjgast-2018-000241</idno><idno type="pmc">PMC6441264</idno><idno type="wicri:Area/Main/Corpus">000479</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000479</idno><idno type="wicri:Area/Main/Curation">000479</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000479</idno><idno type="wicri:Area/Main/Exploration">000479</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en"><i>PNPLA3</i> gene predicts clinical recovery after sustained virological response in decompensated hepatitis C cirrhosis.</title><author><name sortKey="Dunn, Winston" sort="Dunn, Winston" uniqKey="Dunn W" first="Winston" last="Dunn">Winston Dunn</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Vittal, Anusha" sort="Vittal, Anusha" uniqKey="Vittal A" first="Anusha" last="Vittal">Anusha Vittal</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>NIH/NIDDK, Bethesda, MD, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>NIH/NIDDK, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Zhao, Jie" sort="Zhao, Jie" uniqKey="Zhao J" first="Jie" last="Zhao">Jie Zhao</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="He, Jianghua" sort="He, Jianghua" uniqKey="He J" first="Jianghua" last="He">Jianghua He</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Chakraborty, Shweta" sort="Chakraborty, Shweta" uniqKey="Chakraborty S" first="Shweta" last="Chakraborty">Shweta Chakraborty</name><affiliation wicri:level="2"><nlm:affiliation>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Whitener, Melissa" sort="Whitener, Melissa" uniqKey="Whitener M" first="Melissa" last="Whitener">Melissa Whitener</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Fohn, Sara" sort="Fohn, Sara" uniqKey="Fohn S" first="Sara" last="Fohn">Sara Fohn</name><affiliation wicri:level="2"><nlm:affiliation>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Ash, Ryan" sort="Ash, Ryan" uniqKey="Ash R" first="Ryan" last="Ash">Ryan Ash</name><affiliation wicri:level="2"><nlm:affiliation>Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Taylor, Ryan M" sort="Taylor, Ryan M" uniqKey="Taylor R" first="Ryan M" last="Taylor">Ryan M. Taylor</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Olyaee, Mojtaba" sort="Olyaee, Mojtaba" uniqKey="Olyaee M" first="Mojtaba" last="Olyaee">Mojtaba Olyaee</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Olson, Jody C" sort="Olson, Jody C" uniqKey="Olson J" first="Jody C" last="Olson">Jody C. Olson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Todd, Nancy" sort="Todd, Nancy" uniqKey="Todd N" first="Nancy" last="Todd">Nancy Todd</name><affiliation wicri:level="2"><nlm:affiliation>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Floyd, Beth N" sort="Floyd, Beth N" uniqKey="Floyd B" first="Beth N" last="Floyd">Beth N. Floyd</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Pandya, Prashant" sort="Pandya, Prashant" uniqKey="Pandya P" first="Prashant" last="Pandya">Prashant Pandya</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, Kansas City VA Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, Kansas City VA Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Laycock, Melissa" sort="Laycock, Melissa" uniqKey="Laycock M" first="Melissa" last="Laycock">Melissa Laycock</name><affiliation wicri:level="2"><nlm:affiliation>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Schmitt, Timothy" sort="Schmitt, Timothy" uniqKey="Schmitt T" first="Timothy" last="Schmitt">Timothy Schmitt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Weinman, Steven A" sort="Weinman, Steven A" uniqKey="Weinman S" first="Steven A" last="Weinman">Steven A. Weinman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author></analytic><series><title level="j">BMJ open gastroenterology</title><idno type="ISSN">2054-4774</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background</b></p><p>Patients with decompensated hepatitis C virus (HCV) cirrhosis experience various outcomes after sustained virological response (SVR), ranging from clinical recovery to further deterioration. We hypothesised that the genetic risk for steatosis, namely the polymorphisms rs738409 of Patatin-like Phospholipase Domain-Containing 3 (</p></div><div type="abstract" xml:lang="en"><p><b>Methods</b></p><p>We prospectively enrolled 56 patients with Child-Pugh (CPT) B/C cirrhosis who underwent antiviral therapy. The primary outcome was change in CPT score at 12, 24, and 48 weeks after SVR. We used a linear mixed-effects model for analysis.</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>Forty-five patients (</p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>The </p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">30997139</PMID><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2054-4774</ISSN><JournalIssue CitedMedium="Print"><Volume>6</Volume><Issue>1</Issue><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>BMJ open gastroenterology</Title><ISOAbbreviation>BMJ Open Gastroenterol</ISOAbbreviation></Journal><ArticleTitle><i>PNPLA3</i> gene predicts clinical recovery after sustained virological response in decompensated hepatitis C cirrhosis.</ArticleTitle><Pagination><MedlinePgn>e000241</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/bmjgast-2018-000241</ELocationID><Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Patients with decompensated hepatitis C virus (HCV) cirrhosis experience various outcomes after sustained virological response (SVR), ranging from clinical recovery to further deterioration. We hypothesised that the genetic risk for steatosis, namely the polymorphisms rs738409 of Patatin-like Phospholipase Domain-Containing 3 (<i>PNPLA3</i>), rs58542926 of Transmembrane-6-Superfamily-2 (<i>TM6SF2</i>), and rs641738 of Membrane-bound O-acyltransferase Domain-Containing 7 (<i>MBOAT7</i>), is predictive of recovery.</AbstractText><AbstractText Label="Methods" NlmCategory="UNASSIGNED">We prospectively enrolled 56 patients with Child-Pugh (CPT) B/C cirrhosis who underwent antiviral therapy. The primary outcome was change in CPT score at 12, 24, and 48 weeks after SVR. We used a linear mixed-effects model for analysis.</AbstractText><AbstractText Label="Results" NlmCategory="UNASSIGNED">Forty-five patients (<i>PNPLA3</i>: 21 CC, 19 CG, 5 GG) survived to the first endpoint without liver transplantation. The mean change in CPT score at 12, 24, and 48 weeks was -1.57 (SE=0.30), -1.76 (SE=0.32), and -2.0 (SE=0.36), respectively, among the patients with the <i>PNPLA3</i> CC genotype and -0.50 (SE=0.20), -0.41 (SE=0.25), and -0.24 (SE=0.27), respectively, among the other 24 patients. After adjustment for baseline characteristics, the <i>PNPLA3</i> CG/GG genotypes were associated with a 1.29 (SE=0.30, p<0.0001) point higher CPT score. Most of the difference came from differences in hepatic encephalopathy and bilirubin. The results for rs58542926 and rs641738 were not significant.</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">The <i>PNPLA3</i> CG/GG genotypes could identify a subgroup of patients with decompensated HCV cirrhosis that had suboptimal clinical recovery despite SVR. An understanding of the genetic factors that influence clinical outcomes will help target patients for liver transplant based on individual genetic risk factors and provide insight leading to new therapeutic approaches.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dunn</LastName><ForeName>Winston</ForeName><Initials>W</Initials><Identifier Source="ORCID">0000-0002-4246-6998</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vittal</LastName><ForeName>Anusha</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>NIH/NIDDK, Bethesda, MD, United States.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Jianghua</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chakraborty</LastName><ForeName>Shweta</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whitener</LastName><ForeName>Melissa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fohn</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ash</LastName><ForeName>Ryan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Ryan M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olyaee</LastName><ForeName>Mojtaba</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olson</LastName><ForeName>Jody C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Todd</LastName><ForeName>Nancy</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Floyd</LastName><ForeName>Beth N</ForeName><Initials>BN</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pandya</LastName><ForeName>Prashant</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine, Kansas City VA Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laycock</LastName><ForeName>Melissa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Liver Transplant Center, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmitt</LastName><ForeName>Timothy</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weinman</LastName><ForeName>Steven A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Missouri, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K23 DK109294</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>03</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMJ Open Gastroenterol</MedlineTA><NlmUniqueID>101660690</NlmUniqueID><ISSNLinking>2054-4774</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">PNPLA3</Keyword><Keyword MajorTopicYN="N">decompensated cirrhosis</Keyword><Keyword MajorTopicYN="N">hepatitis C</Keyword><Keyword MajorTopicYN="N">recovery</Keyword></KeywordList><CoiStatement>Competing interests: WD reports speaking and consultation fees from Gilead and Merck. RT reports speaking fees from Bristol-Myers Squibb, Gilead, Intercept, Merck and Salix/Valeant, and consultation fees from Bayer and Gilead. PKP reports speaking fees from AbbVie and Gilead.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>09</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>11</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>11</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>4</Month><Day>19</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30997139</ArticleId><ArticleId IdType="doi">10.1136/bmjgast-2018-000241</ArticleId><ArticleId IdType="pii">bmjgast-2018-000241</ArticleId><ArticleId IdType="pmc">PMC6441264</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Hepatology. 2007 Mar;45(3):579-87</Citation><ArticleIdList><ArticleId IdType="pubmed">17326216</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 2008 Sep;48(3):723-31</Citation><ArticleIdList><ArticleId IdType="pubmed">18688878</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Gastroenterol Hepatol. 2011 Jun;9(6):509-516.e1</Citation><ArticleIdList><ArticleId IdType="pubmed">21397729</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 2015 Mar;61(3):812-22</Citation><ArticleIdList><ArticleId IdType="pubmed">25348752</ArticleId></ArticleIdList></Reference><Reference><Citation>J Lipid Res. 2015 Jan;56(1):167-75</Citation><ArticleIdList><ArticleId IdType="pubmed">25378656</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Gastroenterol Hepatol. 2016 Feb;14(2):295-300</Citation><ArticleIdList><ArticleId IdType="pubmed">26305067</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2015 Dec 31;373(27):2618-28</Citation><ArticleIdList><ArticleId IdType="pubmed">26569658</ArticleId></ArticleIdList></Reference><Reference><Citation>World J Gastroenterol. 2015 Dec 14;21(46):12989-95</Citation><ArticleIdList><ArticleId IdType="pubmed">26675364</ArticleId></ArticleIdList></Reference><Reference><Citation>Medicine (Baltimore). 2016 Feb;95(7):e2718</Citation><ArticleIdList><ArticleId IdType="pubmed">26886612</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2016 Jun;16(6):685-697</Citation><ArticleIdList><ArticleId IdType="pubmed">26907736</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Mol Sci. 2016 May 25;17(6):</Citation><ArticleIdList><ArticleId IdType="pubmed">27231906</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hepatol. 2017 Mar;66(3):485-493</Citation><ArticleIdList><ArticleId IdType="pubmed">27780714</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 2017 Mar;65(3):804-812</Citation><ArticleIdList><ArticleId IdType="pubmed">28012259</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 2017 Jun;65(6):1810-1822</Citation><ArticleIdList><ArticleId IdType="pubmed">28170112</ArticleId></ArticleIdList></Reference><Reference><Citation>Hepatology. 2017 Jul;66(1):46-56</Citation><ArticleIdList><ArticleId IdType="pubmed">28257591</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Gastroenterol Hepatol. 2018 Jan;16(1):27-38.e4</Citation><ArticleIdList><ArticleId IdType="pubmed">28479504</ArticleId></ArticleIdList></Reference><Reference><Citation>Obesity (Silver Spring). 2017 Aug;25(8):1360-1368</Citation><ArticleIdList><ArticleId IdType="pubmed">28605159</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hepatol. 2017 Dec;67(6):1204-1212</Citation><ArticleIdList><ArticleId IdType="pubmed">28802876</ArticleId></ArticleIdList></Reference><Reference><Citation>Gastroenterology. 2018 Jun;154(8):2111-2121.e8</Citation><ArticleIdList><ArticleId IdType="pubmed">29535028</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li><li>Missouri (État)</li></region></list><tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Dunn, Winston" sort="Dunn, Winston" uniqKey="Dunn W" first="Winston" last="Dunn">Winston Dunn</name></region><name sortKey="Ash, Ryan" sort="Ash, Ryan" uniqKey="Ash R" first="Ryan" last="Ash">Ryan Ash</name><name sortKey="Chakraborty, Shweta" sort="Chakraborty, Shweta" uniqKey="Chakraborty S" first="Shweta" last="Chakraborty">Shweta Chakraborty</name><name sortKey="Floyd, Beth N" sort="Floyd, Beth N" uniqKey="Floyd B" first="Beth N" last="Floyd">Beth N. Floyd</name><name sortKey="Fohn, Sara" sort="Fohn, Sara" uniqKey="Fohn S" first="Sara" last="Fohn">Sara Fohn</name><name sortKey="He, Jianghua" sort="He, Jianghua" uniqKey="He J" first="Jianghua" last="He">Jianghua He</name><name sortKey="Laycock, Melissa" sort="Laycock, Melissa" uniqKey="Laycock M" first="Melissa" last="Laycock">Melissa Laycock</name><name sortKey="Olson, Jody C" sort="Olson, Jody C" uniqKey="Olson J" first="Jody C" last="Olson">Jody C. Olson</name><name sortKey="Olyaee, Mojtaba" sort="Olyaee, Mojtaba" uniqKey="Olyaee M" first="Mojtaba" last="Olyaee">Mojtaba Olyaee</name><name sortKey="Pandya, Prashant" sort="Pandya, Prashant" uniqKey="Pandya P" first="Prashant" last="Pandya">Prashant Pandya</name><name sortKey="Pandya, Prashant" sort="Pandya, Prashant" uniqKey="Pandya P" first="Prashant" last="Pandya">Prashant Pandya</name><name sortKey="Schmitt, Timothy" sort="Schmitt, Timothy" uniqKey="Schmitt T" first="Timothy" last="Schmitt">Timothy Schmitt</name><name sortKey="Taylor, Ryan M" sort="Taylor, Ryan M" uniqKey="Taylor R" first="Ryan M" last="Taylor">Ryan M. Taylor</name><name sortKey="Todd, Nancy" sort="Todd, Nancy" uniqKey="Todd N" first="Nancy" last="Todd">Nancy Todd</name><name sortKey="Vittal, Anusha" sort="Vittal, Anusha" uniqKey="Vittal A" first="Anusha" last="Vittal">Anusha Vittal</name><name sortKey="Vittal, Anusha" sort="Vittal, Anusha" uniqKey="Vittal A" first="Anusha" last="Vittal">Anusha Vittal</name><name sortKey="Weinman, Steven A" sort="Weinman, Steven A" uniqKey="Weinman S" first="Steven A" last="Weinman">Steven A. Weinman</name><name sortKey="Whitener, Melissa" sort="Whitener, Melissa" uniqKey="Whitener M" first="Melissa" last="Whitener">Melissa Whitener</name><name sortKey="Zhao, Jie" sort="Zhao, Jie" uniqKey="Zhao J" first="Jie" last="Zhao">Jie Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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